ACTA UNIVERSITATIS OULUENSIS C Tec h n i c a 3 5 2

Light scattering diagnostics of turbid media containing both structural and dynamic\ninhomogeneities is currently of significant importance. One of the important directions in modern\nlight scattering diagnostics is the development of methods for probing biological media with\nvisible- and near-infrared radiation allowing for visualization of the biotissue structure. Optical\nmethods for studying the biotissue structure and characterization of its optical properties are very\npromising and have been rapidly developing during the past decade.\nThe present work is aimed at improving and discovering new potentials of currently existing\nmethods of laser diagnostics of biological tissues containing both structural and dynamic\ninhomogeneities. In particular, the feasibilities of spatially resolved reflectometry and time-offlight\ntechniques for the problem of noninvasive determination of glucose level in human blood\nand tissues were examined both numerically and experimentally. The relative sensitivities of these\nmethods to changes in glucose level were estimated. Time-of-flight technique was found to be\nmore sensitive.\nThe possibilities of Doppler optical coherence tomography for imaging of dynamic\ninhomogeneities with high resolution were considered. This technique was applied for the first\ntime for the imaging of complex autowave cellular motility and cytoplasm shuttle flow in the slime\nmold Physarum polycephalum. The effect of multiple scattering on the accuracy of the measured\nflow velocity profiles for the case of single flow and for the case of the flow embedded into the\nstatic medium with strong scattering was studied. It was shown that this effect causes significant\ndistortion to the measured flow velocity profiles and it is necessary to take this into account while\nmaking quantitative measurements of flow velocities.

ISBN-10:
978-951-42-6154-1
Kieli:
eng.
Sivumäärä:
166 s.
Tekijät:
Bykov Alexander
Tuotekoodi 013960
20,00 €