- Oulun yliopisto
- Tampereen yliopisto / Yksiköt
- Lapin yliopisto / University of Lapland
- Lapland University Press / Lapin yliopistokustannus
- Itä-Suomen yliopisto
- Centria-ammattikorkeakoulu, Centria-kirjasto Kokkola
- Vaasan yliopisto
- Tampere University Press. TUP
- Viipurin Suomalainen Kirjallisuusseura
- Humanistinen ammattikorkeakoulu- Humak
- Tampereen teknillisen yliopiston julkaisut
INTRAVENOUS PATIENT CONTROLLED ANALGESIA WITH REMIFENTANIL IN EARLY LABOUR, ACTA UNIVERSITATIS OULUENSIS D Medica 1044In four prospective clinical trials, 114 parturients used intravenous patient-controlled remifentanilanalgesia during the 1st stage of labour. The median effective dose per bolus was ascertained to be0.4 ìg/kg and the pain scores were reduced with this by a median of 2 on a numerical scale (0–10).Compared with nitrous oxide, 15 parturients included in a cross-over study reported a largerreduction in pain scores during remifentanil analgesia (1.5 vs. 0.5, p= 0.001) and better pain reliefscores (2.5 vs. 0.5 on a ranked five point scale 0–4, p \nSide effects of remifentanil analgesia included respiratory depression warranting oxygensupplementation in 33% of parturients. Sedation was experienced by the parturients usingremifentanil and this was scored as stronger than sedation during nitrous oxide and EDA. Thenumber of parturients with nausea did not increase during remifentanil analgesia. Other maternalside effects included dizziness, a difficulty in visual focusing and itching. Foetal heart rate tracingabnormalities were noted. The incidence of abnormal tracings and decreased UapH were notdifferent, however, from that observed during nitrous oxide or EDA. Apgar scores at 1 and 5minute indicated no neonatal depression.
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- Volmanen Petri